Journal
ACS OMEGA
Volume 3, Issue 1, Pages 1220-1230Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.7b01779
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Funding
- CONICET [11220110100965]
- SECyT-UNC
- FONCyT (PICT) [821]
- Natural Sciences and Engineering Research Council of Canada through its Discovery programs
- Canada Research Chairs program
- CONICET
- University of Ottawa
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Photoinduced antibacterial gold nanoparticles were developed as an alternative for the treatment of antibiotic-resistant bacteria. Thanks to the amoxicillin coating, they possess high in vivo stability, selectivity for the bacteria wall, a good renal clearance, and are completely nontoxic for eukaryotic cells at the bactericidal concentrations. A simple one-step synthesis of amoxi@AuNP is described at mild temperatures using the antibiotic as both reducing and stabilizing agent. Time-resolved fluorescence microscopy proved these novel nano-photosensitizers, with improved selectivity, are bactericidal but showing excellent biocompatibility toward eukaryotic cells at the same dose (1.5 mu g/mL) when co-cultures are analyzed. Their stability in biological media, hemocompatibility, and photo-antibacterial effect against sensitive and antibiotic-resistant Staphylococcus aureus were evaluated in vitro, whereas toxicity, renal clearance, and biodistribution were studied in vivo in male Wistar rats. The use of these nanoparticles to treat antibiotic-resistant infections is promising given their high stability and cytocompatibility.
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