Journal
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
Volume 63, Issue -, Pages 61-67Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.niox.2016.09.002
Keywords
Nitric oxide synthase; Cytochrome P450 reductase; Diflavin oxidoreductase; Fluorescence; Protein dynamics
Categories
Funding
- BBSRC/Bruker
- UK Biotechnology and Biological Sciences Research Council
- Engineering and Physical Sciences Research Council [EP/J020192/1]
- BBSRC [BB/H021523/1, BB/M017702/1] Funding Source: UKRI
- EPSRC [EP/J020192/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [1225834, BB/H021523/1, BB/M017702/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/J020192/1] Funding Source: researchfish
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This perspective reviews single molecule and ensemble fluorescence spectroscopy studies of the three tissue specific nitric oxide synthase (NOS) isoenzymes and the related diflavin oxidoreductase cyto chrome P450 reductase. The focus is on the role of protein dynamics and the protein conformational landscape and we discuss how recent fluorescence-based studies have helped in illustrating how the nature of the NOS conformational landscape relates to enzyme turnover and catalysis. (C) 2016 The Authors. Published by Elsevier Inc.
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