Journal
BIOMACROMOLECULES
Volume 19, Issue 5, Pages 1402-1409Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.7b01249
Keywords
-
Funding
- Danish Council for Independent Research, Technology and Productions Sciences
- Lundbeck Foundation
- Danish Ministry of Science, Innovation and Higher Education
- Lundbeck Foundation [R180-2014-3468] Funding Source: researchfish
Ask authors/readers for more resources
Mussel-inspired hydrogels held together by reversible catecholato-metal coordination bonds have recently drawn great attention owing to their attractive self-healing, viscoelastic and adhesive properties together with their pH-responsive nature. A major challenge in these systems is to orchestrate the degree of catechol oxidation that occurs under alkaline conditions in air and has a great impact on the aforementioned properties because it introduces irreversible covalent cross-links to the system, which stiffens the hydrogels but consume catechols needed for self-healing. Herein, we present a catechol-based hydrogel design that allows for the degree of oxidative covalent cross-linking to be controlled. Double cross-linked hydrogels with tunable stiffness are constructed by adding the oxidizable catechol analogue, tannic acid, to an oxidation-resistant hydrogel construct held together by coordination of the dihydroxy functionality of 1-(2'-carboxyethyl)-2-methyl-3-hydroxy-4-pyridinone to trivalent metal ions. By varying the amount of tannic acid, the hydrogel stiffness can be customized to a given application while retaining the self-healing capabilities of the hydrogel's coordination chemical component.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available