Journal
ENDOCRINE-RELATED CANCER
Volume 22, Issue 5, Pages R265-R277Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/ERC-15-0209
Keywords
bladder cancer; androgen receptor; endocrine therapy
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Funding
- US Department of Veterans Affairs, Office of Research and Development, VA MERIT award [BX001079]
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Men are three to four times more likely to get bladder cancer than women. The gender disparity characterizing bladder cancer diagnoses has been investigated. One hypothesis is that androgen receptor (AR) signaling is involved in the etiology and progression of this disease. Although bladder cancer is not typically described as an endocrine-related malignancy, it has become increasingly clear that AR signaling plays a role in bladder tumors. This review summarizes current findings regarding the role of the AR in bladder cancer. We discuss work demonstrating AR expression in bladder cancer and its role in promoting formation and progression of tumors. Additionally, we discuss the therapeutic potential of targeting the AR in this disease.
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