Journal
ENDOCRINE PRACTICE
Volume 21, Issue 8, Pages 936-942Publisher
AMER ASSOC CLINICAL ENDOCRINOLOGISTS
DOI: 10.4158/EP15623.OR
Keywords
-
Categories
Funding
- National Institutes of Health [AG12161]
- N.J.A.E.S [0153866]
- NATIONAL INSTITUTE ON AGING [R29AG012161, R01AG012161] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Objective: To examine the relationship between endogenous serum estradiol and vitamin D-binding protein (DBP) and total, free, and bioavailable 25-hydroxyvitamin D (25OHD) concentrations in pre-and postmenopausal women. Methods: In 165 healthy women (ages, 26 to 75 years) not taking any form of exogenous estrogen, the serum concentrations of estradiol, 25OHD, DBP, parathyroid hormone, and albumin were measured. Free and bioavailable 25OHD (free + albumin-bound) levels were calculated from total 25OHD, DBP, and serum albumin levels. Results: Premenopausal women had higher serum 25OHD (31.5 +/- 7.9 ng/mL), DBP (45.3 +/- 6.2 mg/dL), and estradiol (52.8 +/- 35.0 pg/mL) levels than postmenopausal women (26.5 +/- 4.9 ng/mL, 41.7 +/- 5.7 mg/dL, and 12.9 +/- 4.9 pg/mL), respectively. In addition, the calculated free and bioavailable 25OHD levels were higher in prethan postmenopausal women (P<. 05). Serum estradiol correlated with DBP (r = 0.22; P<. 01) and total 25OHD (r = 0.27; P<. 01). In multivariate regression models (with or without serum 25OHD), estradiol was independently associated with DBP (P<. 05). Conclusion: Lower estradiol level is one of the factors that contribute to lower DBP levels in older women. Our data indicate that besides well-known factors such as age, gender, and race, serum estradiol concentrations are also a physiologic predictor of DBP concentration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available