4.6 Article

Palladium/copper-catalyzed arylation of alkenes with N′-acyl arylhydrazines

Journal

NEW JOURNAL OF CHEMISTRY
Volume 41, Issue 2, Pages 437-441

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nj03718f

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Funding

  1. National Science Fundation of P. R. China [81660573]
  2. National Science Grand Fundation of Guizhou Province [JZ[2016]2001]
  3. Social Development of Technical Supporting Fundation of Guizhou Province [[2016]2819]
  4. PhD Research Foundation of Guizhou Medical University [J[2015]006]

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A novel ligand-free palladium/copper-catalyzed Heck-type coupling reaction of alkenes and N' -acyl arylhydrazines has been developed by using air as the terminal oxidant. This protocol features wide functional group tolerance and produces highly chemoselective and regioselective products with good to excellent yields.

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