Journal
BIOFOULING
Volume 34, Issue 7, Pages 815-825Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927014.2018.1504926
Keywords
Microorganisms; biofilms; terpinen-4-ol
Funding
- Sao Paulo Research Foundation, Brazil, FAPESP [2009/54035-4, 2014/23241-6, 2015/08742-1]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [09/54035-4] Funding Source: FAPESP
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This study evaluated the antibacterial activity of terpinen-4-ol against Streptococcus mutans and Lactobacillus acidophilus and its influence on gbpA (S. mutans) and slpA (L. acidophilus) gene expression. As measured by XTT assay, the concentrations of terpinen-4-ol that effectively inhibited the biofilm were 0.24% and 0.95% for S. mutans and L. acidophilus, respectively. Confocal microscopy revealed the presence of a biofilm attached to the enamel and dentin block surfaces with significant terpinen-4-ol effects against these microorganisms. The expression of the gbpA and slpA genes involved in adherence and biofilm formation was investigated using RT-PCR. Expression of these genes decreased after 15min with 0.24% and 0.95% terpinen-4-ol in S. mutans and L. acidophilus, respectively. These findings demonstrate the antimicrobial activity of terpinen-4-ol and its ability to modulate the expression of gbpA and slpA genes, emphasizing the therapeutic capacity of terpinen-4-ol as an alternative to inhibit adherence in biofilm.
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