Journal
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
Volume 51, Issue 4, Pages 1830-1838Publisher
KARGER
DOI: 10.1159/000495684
Keywords
Morin; Chondrocytes; IL-1 beta; NF-kappa B; Nrf2
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Funding
- Research and innovation fund of the first affiliated hospital of Harbin Medical university [2018Y004]
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Background/Aims: Osteoarthritis (OA) is a multifactorial disease that is associated with inflammation in joints. The purpose of the present study was to investigate the anti-inflammatory activity and mechanism of morin on human osteoarthritis chondrocytes stimulated by IL1 beta. Methods: The levels of NO and PGE2 were measured by the Griess method and ELISA. The levels of MMP1, MMP3, and MMP13 were also measured by ELISA. Results: The results revealed that IL-1 beta significantly increased the production of NO, PGE2, MMP1, MMP3, and MMP13. Additionally, the increases were significantly attenuated by treatment with morin. Furthermore, IL-1 beta-induced NF-kappa B activation was suppressed by morin. In addition, the expression of Nrf2 and HO-1 were increased by morin and knockdown of Nrf2 could prevent the anti-inflammatory effects of morin. Conclusion: In conclusion, this study suggested that morin attenuated IL-1 beta-induced inflammation by activating the Nrf2 signaling pathway. (C) 2018 The Author(s) Published by S. Karger AG, Basel.
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