Journal
JOURNAL OF INNATE IMMUNITY
Volume 10, Issue 5-6, Pages 465-478Publisher
KARGER
DOI: 10.1159/000492161
Keywords
Chemokines; Chemokine receptors; Viral infection
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Funding
- Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health
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Viruses use diverse molecular mechanisms to exploit and evade the immune response. Herpesviruses, in particular, encode functional chemokine and chemokine receptor homologs pirated from the host, as well as secreted chemokine-binding proteins with unique structures. Multiple functions have been described for herpesvirus chemokine components, including attraction of target cells, blockade of leukocyte migration, and modulation of gene expression and cell entry by the virus. Here we review current concepts about how human herpesvirus chemokines, chemokine receptors, and chemokine-binding proteins may be used to shape a proviral state in the host. (c) 2018 S. Karger AG, Basel
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