Journal
NEUROTOXICITY RESEARCH
Volume 33, Issue 1, Pages 184-191Publisher
SPRINGER
DOI: 10.1007/s12640-017-9744-7
Keywords
Analytical chemistry; BMAA; AOAC; Methods; 6-Aminoquinolyl-N-hydroxysuccinimidyl carbamate; AQC; HILIC
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beta-N-Methylamino-L-alanine (BMAA) is a non-canonical amino acid implicated as a cause for amyotrophic lateral sclerosis/parkinsonism dementia complex and potentially other neurodegenerative diseases. As interest in this molecule has increased, there has been a proliferation of methods along with a plethora of opinions as to the superiority of some methods over others. We analyzed the literature with reference to BMAA and its naturally occurring isomers, N-(2-aminoethyl) glycine (AEG) and 2,4 diaminobutyric acid (DAB). A comparison of methods, results, and critiques reveal that a single method has been approved by the AOAC but several different methods provide comparable BMAA quantification concentrations in similar tissues. We also describe a productive way to move forward as technology improves and changes.
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