Journal
ISCIENCE
Volume 10, Issue -, Pages 234-+Publisher
CELL PRESS
DOI: 10.1016/j.isci.2018.12.001
Keywords
-
Categories
Funding
- Bordeaux Imaging Center, part of the national infrastructure France-BioImaging [ANR-10INBS-04-0]
- BBSRC [BB/P000479/1]
- MRC [G0802613]
- Sackler Institute for Translational Neurodevelopment
- BBSRC [BB/P000479/1, BB/J018724/1] Funding Source: UKRI
- MRC [G0802613, MR/N026063/1] Funding Source: UKRI
Ask authors/readers for more resources
Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a sub-population of neuronal EphB2 receptors that exhibit directed motion between synapses within the plasma membrane Itself. This receptor movement occurs independently of the cytoskeleton but is dependent on cholesterol and is regulated by neuronal activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available