Journal
NEUROSCIENCE RESEARCH
Volume 124, Issue -, Pages 57-62Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2017.06.002
Keywords
Marmoset; Visual discrimination learning; Reversal learning; Aging
Categories
Funding
- National Science Foundation East Asia and Pacific Summer Internship Program
- Japan Society for the Promotion of Science Summer Program [NSF 1514944]
- Brain Mapping by Integrated Neurotechnologies for Disease Studies from the Ministry of Education, Culture, Sports, and Technology in Japan
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Common marmosets (Callithrix jacchus) have been suggested as a new model for analysis of age-related changes and neurodegenerative diseases. However, the effects of age on learning and memory processes are not well defined within this species. Therefore, we employed visual discrimination and reversal learning tasks to evaluate learning and memory in four aged common marmosets relative to a younger cohort. We found that aged marmosets commit significantly more errors in initial stages of visual discrimination and more perseverative errors in reversal learning, indicating prefrontal dysfunction. However, they showed comparable performance with younger marmosets in the later stages of both tasks. (C) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.
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