Journal
NEUROSCIENCE RESEARCH
Volume 115, Issue -, Pages 1-4Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2016.11.003
Keywords
Drug development; Drug discovery; Translational research; Valley of death; Psychiatric disorders; Dimensional approach; Education
Categories
Funding
- National Institute of Mental Health [MH-094268, MH-075673]
- Silvio O. Conte center [MH-092443, MH-105660]
- National Institute on Drug Abuse [DA-040127]
- National Cancer Institute [R01 CA161056, R01 CA193895]
- National Institute of Neurological Disorders and Stroke [NS077582-01]
- National Center for Advancing Translational Sciences [TR001079]
- Stanley
- S-R
- RUSK
- NARSAD
- Maryland Stem Cell Research Fund
- Kakenhi from Ministry of Education, Culture, Sports, Science and Technology, Japan
- Innovation Fund Denmark
Ask authors/readers for more resources
There is a great need for novel drug discovery for major mental illnesses, but multiple levels of challenges exist in both academia and industry, spanning from scientific understanding and institutional infrastructure to business risk and feasibility. The valley of death, the large gap between basic scientific research and translation to novel therapeutics, underscores the need to restructure education and academic research to cultivate the fertile interface between academia and industry. In this opinion piece, we propose strategies to educate young trainees in the process of drug discovery and development, and prepare them for careers across this spectrum. In addition, we describe a research framework that considers the disease trajectory and underlying biology of mental disorders, which will help to address the core pathophysiology in novel treatments, and may even allow early detection and intervention. We hope that these changes will increase understanding among academia, industry, and government, which will ultimately improve the diagnosis, prognosis and treatment of mental disorders. (c) 2016 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.
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