Journal
NEUROSCIENCE RESEARCH
Volume 116, Issue -, Pages 18-28Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2016.10.003
Keywords
LRRTM; Synapse development; Synaptic plasticity; Synapse formation; Autism; Schizophrenia; Neurodevelopment; Neural circuit; Neurexin; Heparan sulphate proteoglycan; HSPG
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Funding
- NSERC Discovery Grant [RGPIN-2015-05994]
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Leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) are a family of four synapse organizing proteins critical for the development and function of excitatory synapses. The genes encoding LRRTMs and their binding partners, neurexins and HSPGs, are strongly associated with multiple psychiatric disorders. Here, we review the literature covering their structural features, expression patterns in the developing and adult brains, evolutionary origins, and discovery as synaptogenic proteins. We also discuss their role in the development and plasticity of excitatory synapses as well as their disease associations. (C) 2016 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.
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