Journal
NEUROSCIENCE LETTERS
Volume 652, Issue -, Pages 50-55Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2016.09.053
Keywords
ECM; Laminin; Collagen; Fibronectin; Central nervous system; Axon growth; Glial scar; Transplantation
Categories
Funding
- Wings for Life Foundation [WFL-US-015/15]
- Morton Cure Paralysis Fund
- Craig H. Neilsen Foundation [284621]
- Department of Veteran Affairs [I01BX007080]
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There is no treatment for people with spinal cord injury that leads to significant functional improvements. The extracellular matrix is an intricate, 3-dimensional, structural framework that defines the environment for cells in the central nervous system. The components of extracellular matrix have signaling and regulatory roles in the fate and function of neuronal and non-neuronal cells in the central nervous system. This review discusses the therapeutic potential of extracellular matrix components for spinal cord repair. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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