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Neuroprotection and secondary damage following spinal cord injury: concepts and methods

Journal

NEUROSCIENCE LETTERS
Volume 652, Issue -, Pages 3-10

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2016.12.004

Keywords

CNS injury; Neuroprotection; Secondary damage; Spinal cord injury

Categories

Funding

  1. Canadian Institutes of Health Research (CIHR)
  2. Multiple Sclerosis Society of Canada
  3. International Spinal Research Trust
  4. Craig H. Neilsen Foundation
  5. Wings for Life foundation
  6. CIHR Transplant Training Program

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Neuroprotection refers to the attenuation of pathophysiological processes triggered by acute injury to minimize secondary damage. The development of neuroprotective treatments represents a major goal in the field of spinal cord injury (SCI) research. In this review, we discuss the strengths and limitations of the methodologies employed to assess secondary damage and neuroprotection in preclinical models of traumatic SCI. We also discuss modelling issues and how new tools might be exploited to study secondary damage and neuroprotection. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

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