Journal
NEUROSCIENCE LETTERS
Volume 695, Issue -, Pages 65-70Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2017.09.019
Keywords
Pannexin; Src family kinase; Tyrosine phosphorylation; Central nervous system
Categories
Funding
- Canadian Institutes of Health Research (CIHR) [MOP-136812]
- Natural Sciences and Engineering Research Council of Canada [435762-2013]
- CIHR
- Alberta Innovates - Health Solutions
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Pannexins form single membrane channels that regulate the passage of ions, small molecules and metabolites between the intra- and extracellular compartments. In the central nervous system, these channels are integrated into numerous signaling cascades that shape brain physiology and pathology. Post-translational modification of pannexins is complex, with phosphorylation emerging as a prominent form of functional regulation. While much is still not known regarding the specific kinases and modified amino acids, recent reports support a role for Src family tyrosine kinases (SFK) in regulating pannexin channel activity. This review outlines the current evidence supporting SFK-dependent pannexin phosphorylation in the CNS and examines the importance of these modifications in the healthy and diseased brain.
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