Journal
NEUROSCIENCE LETTERS
Volume 644, Issue -, Pages 62-66Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2017.02.040
Keywords
Angiopoietin 1; Tyrosine kinase 2; Bone marrow stromal cells; lschemic stroke; Type 2 diabetes mellitus
Categories
Funding
- National Natural Science Foundation of China [81571155, 81571210, 81201025]
- Jiangsu Provincial Medical Youth Talent [QNRC2016788]
- Summit of Six Top Talents Program of Jiangsu Province [2013-WSN-081]
- Natural science fund for colleges and universities in Jiangsu Province [15KJD320006]
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Our previous studies have found that stem cells conditioned medium (CM) facilitated functional recovery after stroke in non-diabetics. However, whether bone marrow stromal cells conditioned medium (BMSCs-CM) treatment after stroke in type 2 diabetic (T2DM) rats improve functional outcomes remains unclear. T2DM rats were induced and subjected to stroke then treated with or without BMSCs-CM. Functional outcomes and blood-brain barrier (BBB) leakage were performed, the expression of Angiopoietin (Ang) 1 and tyrosine kinase (Tie) 2 were also assessed. Our results showed that BMSCs-CM treatment significantly improved functional outcomes, decreased BBB leakage and the expression of Ang1 and Tie2 were also changed after BMSCs-CM treatment in type 2 diabetes after stroke. In conclusion, enhanced expression of Ang1 and Tie2 in ischemic brain after BMSCs-CM treatment of stroke may contribute to the improved functional recovery after stroke in type 2 diabetic rats. (C) 2017 Elsevier B.V. All rights reserved.
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