Journal
NEUROSCIENCE LETTERS
Volume 652, Issue -, Pages 35-40Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2016.11.004
Keywords
Spinal cord; Regeneration; Sensory neurons; Motor neurons; Grafts
Categories
Funding
- Christopher and Dana Reeve Foundation
- Medical Research Council
- European Research Council ECMneuro
- Cambridge NHMRC Biomedical Research Centre
- MRC [MR/R004544/1] Funding Source: UKRI
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After injury, the adult mammalian central nervous system (CNS) lacks long-distance axon regeneration. This review discusses the similarities and differences of sensory and motor neurons, seeking to understand how to achieve functional sensory and motor regeneration. As these two types of neurons respond differently to axotomy, growth environment and treatment, the future challenge will be on how to achieve full recovery in a way that allows regeneration of both types of fibres simultaneously. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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