Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 117, Issue -, Pages 198-210Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2017.05.016
Keywords
Prenatal stress; DOHaD; Epigenetics; DNA methylation
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Funding
- Canadian Institute of Health Research (CIHR) [MOP-1150067]
- Natural Sciences and Engineering Research Council of Canada [05519]
- EU BRAINAGE [279281]
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In utero exposure to environmental stress in both animals and humans could result in long-term epigenome alterations which further lead to consequences for adaptation and development in the offspring. Epigenetics, especially DNA methylation, is considered one of the most widely studied and well-characterized mechanisms involved in the long-lasting effects of in utero stress exposure. In this review, we outlined evidence from animal and human prenatal research supporting the view that prenatal stress could lead to lasting, broad and functionally organized signatures in DNA methylation which, in turn, could mediate exposure-phenotype associations. We also emphasized the advantage of using stressor from quasi-randomly assigned experiments. Furthermore, we discuss challenges that still need to be addressed in this field in the future.
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