Journal
NEUROSCIENCE
Volume 346, Issue -, Pages 226-237Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2017.01.025
Keywords
epigallocatechin-3-gallate (EGCG); stress; protein kinase C alpha (PKC alpha); extracellular signal-regulated kinase1/2 (ERK1/2); peroxisome proliferators-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha)
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Funding
- National Nature Science Foundation of China (NSFC) [81372987, 81072294]
- National Institute of General Medical Sciences (NIGMS) [R01GM063075]
- National Center of Complementary and Alternative Medicine (NCCAM) [R01AT05076]
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Stress-induced neural injuries are closely linked to the pathogenesis of various neuropsychiatric disorders and psychosomatic diseases. We and others have previously demonstrated certain protective effects of epigallocatechin-3-gallate (EGCG) in stress-induced cerebral impairments, but the underlying protective mechanisms still remain poorly elucidated. Here we provide evidence to support the possible involvement of PKC alpha and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathways in EGCG-mediated protection against restraint stress-induced neural injuries in rats. In both open-field and step-through behavioral tests, the restraint stress-induced neuronal impairments were significantly ameliorated by administration of EGCG or green tea polyphenols (GTPs), which was associated with a partial restoration of normal plasma glucocorticoid, dopamine and serotonin levels. Furthermore, the stress-induced decrease of PKCa and ERK1/2 expression and phosphorylation was significantly attenuated by EGCG and to a less extent by GTP administration. Additionally, EGCG supplementation restored the production of adenosine triphosphate (ATP) and the expression of a key regulator of cellular energy metabolism, the peroxisome proliferators-activated receptor-c coactivator-1 alpha (PGC-1 alpha), in stressed animals. In conclusion, PKC alpha and ERK1/2 signaling pathways as well as PGC-1 alpha-mediated ATP production might be involved in EGCG-mediated protection against stress-induced neural injuries. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
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