THE NEURAL UNDERPINNINGS OF COGNITIVE FLEXIBILITY AND THEIR DISRUPTION IN PSYCHOTIC ILLNESS

Schizophrenia (SZ) has long been associated with a variety of cognitive deficits, including reduced cognitive flexibility. More recent findings, however, point to tremendous inter-individual variability among patients on measures of cognitive flexibility/set-shifting. With an eye toward shedding light on potential sources of variability in set-shifting abilities among SZ patients, I examine the neural substrates of underlying probabilistic reversal learning (PRL) - a paradigmatic measure of cognitive flexibility as well as neuromodulatory influences upon these systems. Finally, I report on behavioral and neuroimaging studies of PRL in SZ patients, discussing the potentially influences of illness profile and antipsychotic medications on cognitive flexibility in SZ. This article is part of a Special Issue entitled: Cognitive Flexibility. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.