Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2018.00011
Keywords
apoptosis; DUBs; E3 ligases; ubiquitination; ubiquitin proteasome system
Categories
Funding
- Research Grant for INSA Young Scientist [SP/YSP/136/2016-1063]
- Council of Scientific and Industrial Research (CSIR) [SPM-07/0512 (0223)/2015-EMR-l]
- Drug Discovery Research Center (DDRC)-Revelation Biotech private limited (RBPL) project at THSTI [THS/6.7.16]
Ask authors/readers for more resources
Regulatory functions of the ubiquitin-proteasome system (UPS) are exercised mainly by the ubiquitin ligases and deubiquitinating enzymes. Degradation of apoptotic proteins by UPS is central to the maintenance of cell health, and deregulation of this process is associated with several diseases including tumors, neurodegenerative disorders, diabetes, and in fl ammation. Therefore, it is the view that interrogating protein turnover in cells can offer a strategy for delineating disease-causing mechanistic perturbations and facilitate identi fi cation of drug targets. In this review, we are summarizing an overview to elucidate the updated knowledge on the molecular interplay between the apoptosis and UPS pathways. We have condensed around 100 enzymes of UPS machinery from the literature that ubiquitinates or deubiquitinates the apoptotic proteins and regulates the cell fate. We have also provided a detailed insight into how the UPS proteins are able to fi ne-tune the intrinsic, extrinsic, and p53-mediated apoptotic pathways to regulate cell survival or cell death. This review provides a comprehensive overview of the potential of UPS players as a drug target for cancer and other human disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available