Journal
CHEMOSENSORS
Volume 6, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/chemosensors6040052
Keywords
integrated optical sensors; monolithic integration; broad-band interferometers; label-free; multiplexed detection; on-site determinations
Funding
- program of Industrial Postdoctoral Scholarships of Stavros Niarchos Foundation
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The article reviews the current status of label-free integrated optical biosensors focusing on the evolution over the years of their analytical performance. At first, a short introduction to the evanescent wave optics is provided followed by detailed description of the main categories of label-free optical biosensors, including sensors based on surface plasmon resonance (SPR), grating couplers, photonic crystals, ring resonators, and interferometric transducers. For each type of biosensor, the detection principle is first provided followed by description of the different transducer configurations so far developed and their performance as biosensors. Finally, a short discussion about the current limitations and future perspectives of integrated label-free optical biosensors is provided.
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