Journal
NEUROPHARMACOLOGY
Volume 112, Issue -, Pages 389-398Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2016.02.029
Keywords
Malaria; Cerebral malaria; Toxoplasma; Kynurenine pathway; Indoleamine 2,3-dioxygenase; Tryptophan; Interferon-gamma
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Funding
- Australian National Health & Medical Research Council
- Australian Research Council
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The kynurenine pathway of tryptophan metabolism has been implicated in brain function, immuno-regulation, anti-microbial mechanisms and pregnancy. Some of these actions are due to depletion of tryptophan and others to the formation of biologically active metabolites. This review focuses on the roles of the kynurenine pathway in host responses during two parasitic diseases of major health and economic importance, malaria and toxoplasmosis, with an emphasis on their impacts on CNS function. This article is part of the Special Issue entitled 'The Kynurenine Pathway in Health and Disease'. (C) 2016 Elsevier Ltd. All rights reserved.
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