Journal
NEUROPHARMACOLOGY
Volume 112, Issue -, Pages 76-83Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2016.08.010
Keywords
Long-term depression, LTD; Short-term potentiation, STP; Long-term potentiation, LTP; NMDA receptors
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Funding
- MRC [G0601812]
- BBSRC [BB/L001977/1]
- NIH [R01MH060252]
- Biotechnology and Biological Sciences Research Council [BB/L001977/1] Funding Source: researchfish
- Medical Research Council [G0601812, MR/K023098/1] Funding Source: researchfish
- BBSRC [BB/L001977/1] Funding Source: UKRI
- MRC [G0601812, MR/K023098/1] Funding Source: UKRI
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In the CM area of the hippocampus N-methyl-D-aspartate receptors (NMDARs) mediate the induction of long-term depression (LTD), short-term potentiation (STP) and long-term potentiation (LTP). All of these forms of synaptic plasticity can be readily studied in juvenile hippocampal slices but the involvement of particular NMDAR subunits in the induction of these different forms of synaptic plasticity is currently unclear. Here, using NVP-AAM077, Ro 25-6981 and UBP145 to target GluN2A-, 2B- and 2D-containing NMDARs respectively, we show that GluN2B-containing NMDARs (GluN2B) are involved in the induction of LTD, STP and LTP in slices prepared from P14 rat hippocampus. A concentration of Ro (1 mu M) that selectively blocks GluN2B-containing diheteromers is able to block LTD. It also inhibits a component of STP without affecting LTP. A higher concentration of Ro (10 mu M), that also inhibits GluN2A/B triheteromers, blocks LTP. UBP145 selectively inhibits the Ro-sensitive component of STP whereas NVP inhibits LTP. These data are consistent with a role of GluN2B diheretomers in LTD, a role of both GluN2B- and GluN2D- containing NMDARs in STP and a role of GluN2A/B triheteromers in LTP. This article is part of the Special Issue entitled 'lonotropic glutamate receptors'. (C) 2016 The Authors. Published by Elsevier Ltd.
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