Journal
NEURON
Volume 95, Issue 4, Pages 817-+Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2017.07.037
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Funding
- Craig Neilsen Foundation
- NINDS [NS096294]
- Wings for Life
- Hong Kong Spinal Cord Injury Fund
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- NIH [P30 HD018655, P30EY012196]
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A major hurdle for functional recovery after both spinal cord injury and cortical stroke is the limited regrowth of the axons in the corticospinal tract (CST) that originate in the motor cortex and innervate the spinal cord. Despite recent advances in engaging the intrinsic mechanisms that control CST regrowth, it remains to be tested whether such methods can promote functional recovery in translatable settings. Here we show that post-lesional AAV-assisted co-expression of two soluble proteins, namely insulin-like growth factor 1 (IGF1) and osteopontin (OPN), in cortical neurons leads to robust CST regrowth and the recovery of CST-dependent behavioral performance after both T10 lateral spinal hemisection and a unilateral cortical stroke. In these mice, a compound able to increase axon conduction, 4-aminopyridine-3-methanol, promotes further improvement in CST-dependent behavioral tasks. Thus, our results demonstrate a potentially translatable strategy for restoring cortical dependent function after injury in the adult.
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