Journal
NEURON
Volume 96, Issue 3, Pages 667-679Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2017.10.015
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Funding
- Koshland Senior Postdoctoral Award
- European Research Council [339495]
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Israel Science Foundation [1284/13]
- Minerva Foundation
- Wellcome Trust [107116/Z/15/Z]
- European Union Horizon Research and Innovation program [739572]
- UK Dementia Research Institute award
- European Research Council (ERC) [339495] Funding Source: European Research Council (ERC)
- Wellcome Trust [107116/Z/15/Z] Funding Source: researchfish
- MRC [UKDRI-1005] Funding Source: UKRI
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Neurons are the largest known cells, with complex and highly polarized morphologies. As such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer mechanisms to convey and integrate information within and between sub-neuronal compartments. Here, we survey different modes of compartmentalized signaling in neurons, highlighting examples wherein the fundamental cell biological processes of protein synthesis and degradation, membrane trafficking, and organelle transport are employed to enable the encoding and integration of information, locally and globally within a neuron. Comparisons to other cell types indicate that neurons accentuate widely shared mechanisms, providing invaluable models for the compartmentalization and transfer mechanisms required and used by most eukaryotic cells.
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