Journal
NEURON
Volume 93, Issue 6, Pages 1388-+Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2017.02.028
Keywords
-
Categories
Funding
- National Science Foundation [DGE 1106400]
- NIH [PN2EY018241, U01MH109069, S10RR028971-01A1]
- NSF [DBI-1041078]
- Helen Wills Neuroscience Institute
Ask authors/readers for more resources
Synaptic connections undergo activity-dependent plasticity during development and learning, as well as homeostatic re-adjustment to ensure stability. Little is known about the relationship between these processes, particularly in vivo. We addressed this with novel quantal resolution imaging of transmission during locomotive behavior at glutamatergic synapses of the Drosophila larval neuromuscular junction. We find that two motor input types, Ib and Is, provide distinct forms of excitatory drive during crawling and differ in key transmission properties. Although both inputs vary in transmission probability, active Is synapses are more reliable. High-frequency firing wakes up'' silent Ib synapses and depresses Is synapses. Strikingly, homeostatic compensation in presynaptic strength only occurs at Ib synapses. This specialization is associated with distinct regulation of postsynaptic CaMKII. Thus, basal synaptic strength, short-term plasticity, and homeostasis are determined input-specifically, generating a functional diversity that sculpts excitatory transmission and behavioral function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available