Journal
NEURON
Volume 96, Issue 6, Pages 1447-+Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2017.11.010
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Funding
- National Institute in Drug Abuse [R01-DA013165]
- National Institute of Neurological Disorders and Stroke (NINDS) [R01NS086104]
- National Institute on Drug Abuse (NIDA) [RO1DA040990]
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Executive control involves the ability to flexibly inhibit or change an action when it is contextually inappropriate. Using the complimentary techniques of human fMRI and monkey electrophysiology in a context-dependent stop signal task, we found a functional double dissociation between the right ventrolateral prefrontal cortex (rVLPFC) and the bi-lateral frontal eye field (FEF). Different regions of rVLPFC were associated with context-based signal meaning versus intention to inhibit a response, while FEF activity corresponded to success or failure of the response inhibition regardless of the stimulus response mapping or the context. These results were validated by electrophysiological recordings in rVLPFC and FEF from one monkey. Inhibition of a planned behavior is therefore likely not governed by a single brain system as had been previously proposed, but instead depends on two distinct neural processes involving different sub-regions of the rVLPFC and their interactions with other motor-related brain regions.
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