Journal
AMERICAN JOURNAL OF CHINESE MEDICINE
Volume 46, Issue 8, Pages 1743-1770Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X1850088X
Keywords
Mulberry; Morus; Diabetes Mellitus; Medicinal Potential; Polyhydroxylated Alkaloids; Review
Funding
- Foundation of Leshan Vocational & Technical College [KY20182016A016]
- Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department [10Y201810]
- Key Research Project of Leshan Science and Technology Bureau [15CXY0012]
- National Natural Science Foundation of China [81603381, 81673691]
- Guangdong Natural Science Foundation [2016A030313008]
- Science and Technology Planning Project of Guangdong Province [2015A020211039]
- Shenzhen Science and Technology Innovation Committee [JCYJ20160518094706544]
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Diabetes mellitus (DM) is a serious metabolic disorder which has reached epidemic proportions all over the world. Despite tremendous developments in medicinal chemistry, traditional medicine is still commonly used for the prevention and treatment of DM. Traditional herbal medicines have played a major role in the management of DM in Asian countries. In particular, mulberry has commonly been utilized in China for the treatment of DM for thousands of years. In the last decade, numerous preclinical findings have suggested that mulberry is a promising therapeutic agent for the treatment of DM, and the polyhydroxylated alkaloids, flavonoids and polysaccharides from mulberry may be the potential active components. The present review systematically summarizes the chemical composition of mulberry and the pharmacological effects of different medicinal parts on DM; these effects include influences on glucose absorption, insulin (INS) production/secretion, anti-oxidation and anti-inflammation processes. After summarizing our research findings, we will discuss the challenges and opportunities and explore the direction of future research and the potential for developing mulberry into pharmaceuticals for the widespread treatment of DM.
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