Journal
NEURON
Volume 94, Issue 1, Pages 193-+Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2017.03.015
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Funding
- FRQS grant from the Quebec bio-Imaging Network [G240856 FRSQ-S/RBIQ, 5886]
- Natural Sciences and Engineering Research Council of Canada [RGPIN2016-04188]
- Canadian Institute for Health Research [FDN143217]
- International Development Research Centre (IDRC), Ottawa, Canada
- FYSSEN foundation
- Banting Fellowship
- Quebec bio-Imaging Network
- Natural Science and Engineering Research Council of Canada [436355-13]
- NIH [2R01EB009048-05]
- Brain Canada Foundation [PSG15-3755]
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The implication of the dorsal stream in manipulating auditory information in working memory has been recently established. However, the oscillatory dynamics within this network and its causal relationship with behavior remain undefined. Using simultaneous MEG/ EEG, we show that theta oscillations in the dorsal stream predict participants' manipulation abilities during memory retention in a task requiring the comparison of two patterns differing in temporal order. We investigated the causal relationship between brain oscillations and behavior by applying thetarhythmic TMS combined with EEG over the MEGidentified target (left intraparietal sulcus) during the silent interval between the two stimuli. Rhythmic TMS entrained theta oscillation and boosted participants' accuracy. TMS-induced oscillatory entrainment scaled with behavioral enhancement, and both gains varied with participants' baseline abilities. These effects were not seen for a melody-comparison control task and were not observed for arrhythmic TMS. These data establish theta activity in the dorsal stream as causally related to memory manipulation.
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