Journal
JOURNAL OF IMAGING
Volume 4, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/jimaging4120146
Keywords
photoacoustic tomography; gold nanospheres; plasmonic nanoparticles; image analysis
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Funding
- European Research Commission (ERC) [281356]
- European Research Council (ERC) [281356] Funding Source: European Research Council (ERC)
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The photoacoustic (PA) signal amplitude measured in gold nanosphere suspensions has been shown to increase nonlinearly with the incident excitation fluence. In this work, this effect is exploited to recover the spatial distribution of gold nanoparticles in tomographic 3D photoacoustic (PA) images against the background contrast provided by absorbers that exhibit a linear relationship between the PA signal amplitude and the fluence. Serial tomographic PA images of a tissue phantom containing gold nanospheres and a tissue-mimicking absorber were acquired. By assessing the linearity of the PA intensity voxel by voxel, the spatial distribution of the gold nanosphere suspension was recovered. The method is shown to enable the robust detection of gold nanoparticles.
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