Journal
NEUROLOGY
Volume 89, Issue 14, Pages 1464-1470Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000004533
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Funding
- NIH Office of the Director [DP5OD019833]
- Massachusetts General Hospital ECOR [1200-228010]
- NIH NIA [K23AG044431]
- Alzheimer's Association [NIRG-12-243012]
- COLCIENCIAS-Colombia [1115-408-20512, 1115-545-31651]
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Objective: To cross-sectionally study subjective memory complaints (SMC) in autosomal dominant Alzheimer disease (ADAD). Methods: We examined self-reported and study partner-based SMC in 52 young, cognitively unimpaired individuals from a Colombian kindred with early-onset ADAD. Twenty-six carried the PSEN-1 E280A mutation, averaging 7 years of age younger than the kindred's expected clinical onset. Twenty-six were age-matched noncarriers. Participants also underwent structural MRI and cognitive testing. Results: Self-reported SMC were greater in carriers than noncarriers (p = 0.02). Study partner-based SMC did not differ between groups (p = 0.21), but in carriers increased with age (r = 0.66, p < 0.001) and decreased with hippocampal volume (r = -20.35, p = 0.08). Conclusions: Cognitively unimpaired PSEN-1 carriers have elevated SMC. Self-reported SMC may be a relatively early indicator of preclinical AD, while partner-reported SMC increases later in preclinical AD, closer to clinical onset.
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