4.5 Article

Increased infections with β-blocker use in ischemic stroke, a β2-receptor mediated process?

Journal

NEUROLOGICAL SCIENCES
Volume 38, Issue 6, Pages 967-974

Publisher

SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-017-2877-x

Keywords

Stroke; Adrenergic beta-antagonists; Propensity score; Infection; Outcome studies

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Strokes promote immunosuppression, partially from increased sympathetic activity. Altering sympathetic drive with beta-blockers has variably been shown to improve stroke outcomes. This study adds to this literature using propensity score matching to limit confounding and by examining the effects of selective and non-selective beta-blockers. Prospective data from acute ischemic stroke admissions at a single center from July 2010-June 2015 were analyzed. Outcomes included infection (urinary tract infection [UTI], pneumonia, or bacteremia), discharge modified Rankin Score (mRS), and in-hospital death. Any selective and non-selective beta-blocker use during the first 3 days of admission were investigated with propensity score matching. A sensitivity analysis was also performed. This study included 1431 admissions. Any beta-blocker use was associated with increased infections (16.4 vs. 10.7%, p = 0.030). Non-selective beta-blocker use was associated with increased infections (18.9 vs. 9.7%, p = 0.005) and UTIs (13.0 vs. 5.5%, p = 0.009). Selective beta-blocker use was not associated with infection. There were no associations between beta-blocker use and in-hospital death or discharge mRS. In the sensitivity analysis, the association between non-selective beta-blocker use and urinary tract infections persisted (12.5 vs. 4.2%, p = 0.044). No associations with death or mRS were found. Early beta-blocker use after ischemic stroke may increase the risk of infection but did not change disability or mortality risk. The mechanism may be mediated by beta(2)-adrenergic receptor antagonism given the different effects seen with selective versus non-selective beta-blocker use.

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