4.5 Article

Diagnostics of autoimmune encephalitis associated with antibodies against neuronal surface antigens

Journal

NEUROLOGICAL SCIENCES
Volume 38, Issue -, Pages S225-S229

Publisher

SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-017-3032-4

Keywords

Anti-contactin-associated protein-like 2 (CASPR2) antibodies; Anti-leucine-rich glioma inactivated 1 (LGI1) antibodies; Anti-N-methyl-D-aspartate receptor (NMDA-R) antibodies; Cell-based assays; Laboratory diagnostics

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This document presents the guidelines for testing antibodies against neuronal surface antigens that have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AIM) congresses. Essential clinical information on autoimmime encephalitis associated with antibodies against neuronal surface antigens, indications and limits of testing for such antibodies, instructions for result interpretation, and an agreed laboratory protocol (Appendix A) are reported for the communicative community of neurologists and clinical pathologists.

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