Journal
NEUROLOGICAL SCIENCES
Volume 38, Issue 8, Pages 1505-1508Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-017-2961-2
Keywords
Deep brain stimulation; Constant current; Parkinson's disease; Subthalamic nucleus; Executive functions
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Funding
- Medtronic
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The study aimed to evaluate safety and efficacy of shifting stimulation settings from constant-voltage (CV) to constant-current (CC) programming in patients with Parkinson's disease (PD) and chronic subthalamic nucleus deep brain stimulation (STN DBS). Twenty PD patients with chronic STN DBS set in CV programming were shifted to CC and followed for 3 months; the other stimulation settings and the medication regimen remained unchanged. Side effects, motor, non-motor, executive functions, and impedance were assessed at baseline and during follow-up. No adverse events were observed at time of shifting or during CC stimulation. Motor and non-motor measures remained unchanged at follow-up despite impedance decreased. Compared to baseline, inhibition processes improved at follow-up. The shifting strategy was well tolerated and the clinical outcome was maintained with no need to adjust stimulation settings or medications notwithstanding a decrease of impedance. Improvement of inhibition processes is a finding which needed further investigation.
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