Journal
NEUROLOGIC CLINICS
Volume 35, Issue 4, Pages 655-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2017.06.004
Keywords
Spreading depolarization; Spreading depression; Delayed cerebral ischemia; Cortical spreading depression; Cerebral blood flow; Subarachnoid hemorrhage; Stroke; Spreading ischemia
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Spreading depolarization in cerebral cortex is associated with swelling of neurons, distortion of dendritic spines, massive ion translocation with a large change of the slow electrical potential, and silencing of brain electrical activity. The term spreading depression represents a wave of spontaneous activity of the electrocorticogram that propagates through contiguous cerebral gray matter at a characteristic velocity. Spreading depression is a consequence of cortical spreading depolarization. Therefore, spreading depolarization is not always accompanied by spreading depression and the terms are not synonymous.
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