Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 50, Issue 11, Pages 1114-1120Publisher
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmy115
Keywords
keloid fibroblasts; gallic acid; proliferation; migration; matrix metalloproteinase
Categories
Funding
- National Natural Science Foundation of China [81272109]
Ask authors/readers for more resources
Keloids are a fibroproliferative disorder of the skin resulted from abnormal healing of injured or irritated skin and are characterized by the ability to spread beyond the original boundary of the wound. Here, we tested the effect of gallic acid (GA), a plant polyphenol with selective growth inhibitory effects in cancer, on the proliferation and invasion of keloid fibroblasts (KFs) isolated from patients undergoing surgery. GA inhibited KF proliferation, migration, and invasion in parallel with the downregulation of matrix metalloproteinase-1 and -3 and upregulation of tissue inhibitors of metalloproteinase-1. Flow cytometric analysis showed that GA inhibited cell cycle progression and induced apoptosis. The effects of GA on KFs occurred in parallel with the inhibition of AKT and ERK1/2, suggesting that GA acts by suppressing the AKT/ERK signaling pathway. In ex vivo explant cultures of keloid tissues, GA inhibited the migration of KFs to the wound area and suppressed the expression of angiogenic markers concomitant with the inhibition of collagen deposition. These results identify GA as a potential therapeutic agent for the treatment of keloids and suggest a potential mechanism underlying its protective effect.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available