Journal
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
Volume 40, Issue 5, Pages 415-422Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08923973.2018.1519831
Keywords
Mangostin; acne; Propionibacterium acnes; keratinocyte; inflammation
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Funding
- Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences
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Objective: Acne is a chronic skin disease that involves four key pathogenic factors: excess sebum production, ductal epidermal hyperproliferation, Propionibacterium acnes (P. acnes) colonization, and skin inflammation. Mangostins are well-known for their anti-bacterial and anti-inflammatory effects, suggesting that mangostins may have therapeutic potential for acne. The present study aimed to explore the anti-acne effects of mangostins from the perspective of multiple pathogenic mechanisms of acne. Methods: The effects of alpha- and gamma-mangostins on the growth of P. acnes and lipase activity were analyzed. Their effects on P. acnes-induced keratinocyte proliferation were examined by CCK-8. The expression of inflammatory genes and activation of NF-kappa B and MAPK signaling pathways were detected by quantitative real-time PCR and western blotting, respectively. Results: Alpha- and gamma-mangostins not only inhibited the growth of P. acnes, but also reduced the proliferation of keratinocytes induced by heat-killed P. acnes. Furthermore, alpha- and gamma-mangostins were able to suppress P. acnes-induced expression of pro-inflammatory cytokines, including TNF-gamma, IL-1 beta, and IL-6 in keratinocytes by inhibiting the activation of NF-kappa B and MAPK signaling pathways. Discussion and conclusions: Mangostins appeared to possess multiple anti-acne activities, including the inhibition of P. acnes growth, regulation of keratinocytes proliferation, and attenuation of skin inflammatory reaction. Hence, mangostins might be developed into a potential therapeutic agent for the treatment of acne.
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