Journal
NEUROGASTROENTEROLOGY AND MOTILITY
Volume 30, Issue 3, Pages -Publisher
WILEY
DOI: 10.1111/nmo.13240
Keywords
functional lumen imaging probe; GERD; impedance; peristalsis; reflux
Funding
- Northwestern Digestive Health Foundation
- National Institutes of Health from the Public Health service [R01 DK092217]
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BackgroundIncreased esophagogastric junction (EGJ) distensibility is thought to contribute to gastroesophageal reflux disease (GERD). Using the functional lumen imaging probe (FLIP), we aimed to assess the esophageal response to distension among patients undergoing esophageal pH monitoring. Methods25 patients (ages 22-73; 13 females) who underwent ambulatory wireless esophageal pH testing while off proton-pump inhibitors were evaluated with FLIP during sedated upper endoscopy. Esophageal reflux was quantified by total percent acid exposure time (AET; <6% was considered normal). FLIP studies were analyzed using a customized program generate FLIP topography plots to identify esophageal contractility patterns and to calculate the EGJ-distensibility index (DI). Reflux symptoms were assessed with the GERDQ. Values reflect median (interquartile range). ResultsAmong all patients, the AET was 7.2% (3.7-11.1) and EGJ-DI was 4.2 (2.5-7.6)mm(2)/mmHg. Repetitive antegrade contractions (RACs) were induced in 19/25 (76%) of patients; AET was lower among patients with (6.1%, 3-7.8) than without (14.9, 8.5-22.3) RACs (P=.009). Correlation was weak and insignificant between AET and EGJ-DI, GERDQ and AET, and GERDQ and EGJ-DI. Patients with abnormal AET (n=16) and normal AET (n=9) had similar EGJ-DI, 4.6mm(2)/mmHg (2.9-9.2) vs 3.2 (2.2-5.1), P=.207 and GERDQ, P=.138. ConclusionsAbnormal esophageal acid exposure was associated with an impaired contractile response to volume distention of the esophagus. This supports that acid exposure is dependent on acid clearance mechanisms.
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