Journal
NEUROGASTROENTEROLOGY AND MOTILITY
Volume 29, Issue 3, Pages -Publisher
WILEY
DOI: 10.1111/nmo.13038
Keywords
classical and non-classical cannabinoid receptors; endocannabinoid metabolism; gastrointestinal tract; inflammation
Funding
- Medical University of Lodz [503/1-156-04/503-11-001, 564/1-000-00/564-20-010]
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In this mini-review, we focus on the potential of the endocannabinoid system as a target for novel therapies to treat gastrointestinal (GI) inflammation. We discuss the organization of the endocannabinoid signaling and present possible pharmacological sites in the endocannabinoid system. We also refer to recent clinical findings in the field. Finally, we point at the potential use of cannabinoids at low, non-psychoactive doses to counteract non-inflammatory pathological events in the GI tract, like chemotherapy-induced diarrhea, as evidenced by Abalo etal. in the rat model.
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