Journal
EMBO JOURNAL
Volume 34, Issue 5, Pages 579-580Publisher
WILEY
DOI: 10.15252/embj.201590971
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Funding
- NIGMS NIH HHS [R01 GM067014] Funding Source: Medline
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1025830] Funding Source: National Science Foundation
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The de novo silencing of transposable elements in plants and animals is mediated in part by RNA-directed chromatin modification. In flowering plants, AGO4 has been seen as the key argonaute protein in the RNA-directed DNA methylation pathway that links the plant-specific RNA polymerase V with the de novo DNA methyltransferase DRM2 (Zhong et al, 2014). Two recent papers in The EMBO Journal strongly implicate a role for the AGO6 protein in the process of de novo silencing.
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