Journal
EMBO JOURNAL
Volume 34, Issue 20, Pages 2486-2488Publisher
WILEY-BLACKWELL
DOI: 10.15252/embj.201592857
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Funding
- Medical Research Council [MC_U117565398] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007270, R01 GM088055] Funding Source: Medline
- MRC [MC_U117565398] Funding Source: UKRI
- Medical Research Council [MC_U117565398] Funding Source: researchfish
- The Francis Crick Institute [10142] Funding Source: researchfish
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Disposal of damaged mitochondria is tightly controlled by auto-inhibition mechanisms that keep the ubiquitin ligase Parkin in check. Several new structural studies provide insight into how PINK1-dependent phosphorylation of ubiquitin and Parkin may progressively relieve Parkin auto-inhibition.
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