Journal
ANTIBIOTICS-BASEL
Volume 7, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/antibiotics7030079
Keywords
silver; antibiotics; adjuvant; combinatorial; metal; ROS
Categories
Funding
- Joint Programming Initiative on Antimicrobial Resistance (JPIAMR)/Agence Nationale de la Recherche (ANR) [ANR-15-JAMR-0003-02]
- Fondation pour la Recherche Medicale (FRM)
- CNRS
- Aix Marseille Universite
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The therapeutic arsenal against bacterial infections is rapidly shrinking, as drug resistance spreads and pharmaceutical industry are struggling to produce new antibiotics. In this review we cover the efficacy of silver as an antibacterial agent. In particular we recall experimental evidences pointing to the multiple targets of silver, including DNA, proteins and small molecules, and we review the arguments for and against the hypothesis that silver acts by enhancing oxidative stress. We also review the recent use of silver as an adjuvant for antibiotics. Specifically, we discuss the state of our current understanding on the potentiating action of silver ions on aminoglycoside antibiotics.
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