Journal
NEUROBIOLOGY OF DISEASE
Volume 97, Issue -, Pages 80-89Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2016.01.021
Keywords
GDNF; Parkinson's disease; Neuropsychiatric disorders
Categories
Funding
- National Medical Research Council of Singapore [CBRG13nov012]
- Ministry of Education of Singapore [MOE2014-T2-1-120]
- National University of Singapore (Start-Up and Strategic ODPRT Awards)
- European Research Council [339237-p75ntr]
- Swedish Research Council [K2012-63X-10908-19-5]
- Swedish Cancer Society [13-0676]
- Karolinska Institute
- Knut and Alice Wallenberg Foundation [KAW 2012.0270]
- Academy of Finland [136591, 140983, 263700]
- Institute of Biotechnology, Helsinki University
- Academy of Finland (AKA) [136591, 263700, 136591, 140983, 263700, 140983] Funding Source: Academy of Finland (AKA)
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A targeted effort to identify novel neurotrophic factors for midbrain dopaminergic neurons resulted in the isolation of GDNF (glial cell line-derived neurotrophic factor) from the supernatant of a rat glial cell line in 1993. Over two decades and 1200 papers later, the GDNF ligand family and their different receptor systems are now recognized as one of the major neurotrophic networks in the nervous system, important for the development, maintenance and function of a variety of neurons and glial cells. The many ways in which the four members of the GDNF ligand family can signal and function allow these factors to take part in the control of multiple types of processes, from neuronal survival to axon guidance and synapse formation in the developing nervous system, to synaptic function and regenerative responses in the adult. In this review, we will briefly summarize basic aspects of GDNF signaling mechanisms and receptor systems and then review our current knowledge of the physiology of GDNF activities in the central nervous system, with an eye to its relevance for neurodegenerative and neuropsychiatric diseases. (C) 2016 Elsevier Inc. All rights reserved.
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