Journal
NEUROBIOLOGY OF AGING
Volume 56, Issue -, Pages 33-40Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2017.03.034
Keywords
Alzheimer's disease; Risk factors; IWG-2 criteria; NIA-AA criteria; Biomarkers; Prognosis
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Funding
- CIHR Funding Source: Medline
- NIA NIH HHS [U01 AG024904] Funding Source: Medline
- Fundação para a Ciência e a Tecnologia [PIC/IC/83206/2007] Funding Source: FCT
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We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Coxregression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hyper-cholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD. (C) 2017 Elsevier Inc. All rights reserved.
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