Journal
NEUROBIOLOGY OF AGING
Volume 58, Issue -, Pages 213-224Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2017.06.009
Keywords
MCI; PET; EEG; Alpha rhythm; CSF; MRI
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Funding
- European Community's Seventh Framework Programme for the Innovative Medicine Initiative [115009]
- Italian Ministry of Health [GR2011-02349787]
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In Alzheimer's disease (AD) research, both 2-deoxy-2-(F-18)fluoro-D-glucose (FDG) positron emission tomography (PET) and electroencephalography (EEG) are reliable investigational modalities. The aim of this study was to investigate the associations between EEG High-alpha/Low-alpha (H-alpha/L-alpha) power ratio and cortical glucose metabolism. A total of 23 subjects with mild cognitive impairment (MCI) underwent FDG-PET and EEG examinations. H-alpha/L-alpha power ratio was computed for each subject and 2 groups were obtained based on the increase of the power ratio. The subjects with higher H-alpha/ L-alpha power ratio showed a decrease in glucose metabolism in the hub brain areas previously identified as typically affected by AD pathology. In subjects with higher H-alpha/L-alpha ratio and lower metabolism, a double alpha peak was identified in the EEG spectrum and a U-shaped correlation between glucose metabolism and increase of H-alpha/L-alpha power ratio has been found. Moreover, in this group, a conversion rate of 62.5% at 24 months was detected, significantly different from the chance percentage expected. The neurophysiological meaning of the interplay between alpha oscillations and glucose metabolism and the possible interest of the H-alpha/L-alpha power ratio as a clinical biomarker in AD have been discussed. (C) 2017 Elsevier Inc. All rights reserved.
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