Journal
NEUROBIOLOGY OF AGING
Volume 54, Issue -, Pages 199-213Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2017.01.027
Keywords
Magnetic resonance imaging; Diffusion tensor imaging; Cognition; Cortex; Mediation
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Funding
- NIH [R01 AG039684]
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Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function. (C) 2017 Elsevier Inc. All rights reserved.
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