Journal
NEURO-ONCOLOGY
Volume 19, Issue 6, Pages 862-870Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/now256
Keywords
1p/19q codeletion; IDH1 mutation; lower-grade gliomas; MR imaging; texture analysis
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Funding
- Natural Science Foundation of China [81301988, 2014-1, 2016-12]
- China Ministry of Education Doctoral Program Spot Foundation [20130162120061]
- Shenghua Yuying Project of Central South University
- Natural Science Foundation of Hunan Province of China [2014-1, 2016-12, 14JJ2042]
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Background. Previous studies have shown that MR imaging features can be used to predict survival and molecular profile of glioblastoma. However, no study of a similar type has been performed on lower-grade gliomas (LGGs). Methods. Presurgical MRIs of 165 patients with diffuse low-and intermediate-grade gliomas (histological grades II and III) were scored according to the Visually Accessible Rembrandt Images (VASARI) annotations. Radiomic models using automated texture analysis and VASARI features were built to predict isocitrate dehydrogenase 1 (IDH1) mutation, 1p/19q codeletion status, histological grade, and tumor progression. Results. Interrater analysis showed significant agreement in all imaging features scored (k = 0.703-1.000). On multivariate Cox regression analysis, no enhancement and a smooth non-enhancing margin were associated with longer progression-free survival (PFS), while a smooth non-enhancing margin was associated with longer overall survival (OS) after taking into account age, grade, tumor location, histology, extent of resection, and IDH1 1p/19q subtype. Using logistic regression and bootstrap testing evaluations, texture models were found to possess higher prediction potential for IDH1 mutation, 1p/19q codeletion status, histological grade, and progression of LGGs than VASARI features, with areas under the receiver-operating characteristic curves of 0.86 +/- 0.01, 0.96 +/- 0.01, 0.86 +/- 0.01, and 0.80 +/- 0.01, respectively. Conclusion. No enhancement and a smooth non-enhancing margin on MRI were predictive of longer PFS, while a smooth non-enhancing margin was a significant predictor of longer OS in LGGs. Textural analyses of MR imaging data predicted IDH1 mutation, 1p/19q codeletion, histological grade, and tumor progression with high accuracy.
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